Tadalafil typically begins to work within 30 to 60 minutes after taking it, though it can vary from person to person. It reaches its peak effectiveness within about 2 hours.

Key factors affecting onset time include: Dosage (Higher doses (20 mg) might take effect slightly faster), Food intake (Eating a heavy or fatty meal may delay its onset), Individual metabolism (Personal metabolism and health conditions affect response time).

Tadalafil has a long duration of action, typically lasting up to 36 hours, earning it the nickname "the weekend pill."

If you're taking tadalafil daily for erectile dysfunction, you'll maintain a consistent level in your body, allowing spontaneous sexual activity at any time without waiting.

For best results, take it at least 30 minutes before sexual activity.